Г.А. Жулай, Е.К. Олейник, П.Н. Кравченко, А.В. Чуров, В.М. Олейник, А.В. Головин, В.А. Толлер, К.А. Островский.
Анализ клеточного иммунитета при патологиях, сопровождающихся развитием иммунной супрессии
// Труды КарНЦ РАН. No 5. Сер. Экспериментальная биология. 2014. C. 228-233
G.A. Zhulai, E.K. Oleinik, P.N. Kravchenko, A.V. Churov, V.M. Oleinik, A.V. Golovin, V.A. Toller, K.A. Ostrovskii. Analysis of cellular immunity in pathologies accompanied by the development of immune suppression // Transactions of Karelian Research Centre of Russian Academy of Science. No 5. Experimental biology. 2014. Pp. 228-233
Keywords: lymphocytes, Treg cells, FOXP3, colorectal cancer, acute pancreatitis, immune suppression
Changes in cellular immunity in patients with gastrointestinal diseases, where the pathogenesis is accompanied by the formation of immune suppression: patients with colorectal cancer (CRC, n = 20) and patients with severe acute pancreatitis (AP, n = 16), were assessed. The control group consisted of 14 healthy donors. Indications of a developing secondary immunodeficiency were observed in patients. The content of some lymphocyte subsets was reduced in comparison with the control. The immunoregulatory index shifled downwards. It is noteworthy that the content of peripheral CD4+ CD25+FOXP3+ Treg cells in both CRC and AP patients increased in comparison with the control.
