Sulfide Cu-Ni deposits form a specific ore formation not only in terms of sustainable association of basic sulfide minerals but also based on its initial connection with maficultramafic intrusions of the mantle origin and the tectonic position within the Pechenga paleorift of the Kola Geoblock of the Baltic Shield. The geologico-structural position of the Pechenga paleoproterosoic riftogenic structure evolving from 2450 Ma through the stages of continental (2340–2130 Ma) and oceanic riftogenesis (2100–1940 Ma) and subsequent collision (1900–1850 Ma) are analyzed in the paper. The last stage was particularly clear in the sulfide Cu-Ni ore forming processes that constitute the central part of the research. Based on S and Pb isotope data the nature of the main epigenetic ores of the current Pechenga deposits is found to be metamorphogenic-hydrothermal and all Cu-Ni ores of the Pechenga ore field are concluded to be of complex polygenic-polichronous genesis.