Е.А. Хижкин, Т.Н. Ильина, Т.А. Лотош, В.А. Илюха, И.А. Виноградова, В.Н. Анисимов.
Влияние постоянного освещения на антиоксидантную систему крыс зависит от возраста животных
// Труды КарНЦ РАН. No 2. Сер. Экспериментальная биология. 2010. C. 62-67
E.A. Khizhkin, T.N. Ilyina, T.A. Lotosh, V.A. Ilukha, I.A. Vinogradova, V.N. Anisimov. Effect of continuous light on rats antioxidant system is depend on animals age // Transactions of Karelian Research Centre of Russian Academy of Science. No 2. Experimental biology. 2010. Pp. 62-67
Keywords: light-at-night, antioxidant enzymes, life span
We evaluated the effect of exposure to constant light started at the age of 1 month and at the age of 14 months on the survival, life span and age-related dynamics of activity antioxidant enzymes and level of .-tocopherol in various organs in comparison to the rats maintained at the standard (12 : 12) light/dark regimen. The exposure to constant light started at the age of 14 months delayed aging of enzymatic and non-enzymatic component of antioxidant defence system that, probably, is one of the reasons of prolongation of a life span of animals. Circadian disruption induced by light-at-night started at the age of 1 month accelerates aging.
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