Макеева (Курбатова) И.В., Коломейчук С.Н., Топчиева Л.В., Корнева В.А., Немова Н.Н.
Связь полиморфных маркеров 3111Т/С и 843Т/С гена CLOCK с риском развития эссенциальной артериальной гипертензии и ишемической болезни сердца у жителей Республики Карелия
// Труды КарНЦ РАН. No 3. Сер. Экспериментальная биология. 2011. C. 88-96
I.V. Makeeva (Kurbatova), S.N. Kolomeichuk, L.V. Topchieva, V.A. Korneva, N.N. Nemova. Association of 3111Т/С and 843Т/С polymorphisms of the CLOCK gene with the risk of essential hypertension and coronary artery disease development in a sample of the russian population (Republic of Kar // Transactions of Karelian Research Centre of Russian Academy of Science. No 3. Experimental biology. 2011. Pp. 88-96
Keywords: cardiovascular diseases, essential hypertension, coronary heart disease, circadian genes, polymorphism.
Allele and genotype frequency distribution of 3111T/C and 843T/C polymorphisms of the CLOCK gene was studied among patients with essential hypertension, coronary artery disease and healthy volunteers from Republic of Karelia. It was shown that the distribution of genotype frequencies was different in patients with these cardiovascular diseases and in the control group. The presence of the CC genotype of 3111T/C and 843T/C polymorphisms results in increased risk of essential hypertension and coronary heart disease in the male population of Karelia.
