Г.А. Жулай, Е.К. Олейник.
Регуляторные т-лимфоциты CD4+CD25+FOXP3+. Перспективы применения в иммунотерапии
// Труды КарНЦ РАН. No 2. Сер. Экспериментальная биология. 2012. C. 3-17
G.A. Zhulaj, E.K. Oleinik. CD4+CD25+FOXP3+ regulatory t,lymphocyte. prospective applications in immunotherapy // Transactions of Karelian Research Centre of Russian Academy of Science. No 2. Experimental biology. 2012. Pp. 3-17
Keywords: Treg cells, phenotype, immunosuppression, tumor, autoimmunity
The review considers basic issues of the biology of CD4+CD25+FOXP3+ regulatory T (Treg) cells, their phenotypic and functional diversity, as well as molecular and cellular mechanisms of Treg cell suppression. Also in the review, the recent data on the frequency and distribution of Treg cells we present in normal and pathology (autoimmunity disease and cancer) conditions. Modern approaches in immunotherapy of these diseases directed on Treg cells are discussed.
