Е.В. Борвинская, Л.П. Смирнов, Н.Н. Немова.
Глутатион-S-трансферазы рыб – потенциальные эколого-биохимические индикаторы антропогенного воздействия на водную среду (обзор)
// Труды КарНЦ РАН. No 3. Сер. Экспериментальная биология. 2009. C. 8-19
E.V. Borvinskaya, L.P. Smirnov, N.N. Nemova. Glutathione-S-transferases in fish – indicators of human impact on the aquatic environment // Transactions of Karelian Research Centre of Russian Academy of Science. No 3. Experimental biology. 2009. Pp. 8-19
Keywords: glutathione-S-transferase, fish, heavy metals, polychlorinated biphenyls, polyaromatic hydrocarbons, mixed pollution.
The review evaluates how well the problem of the effect of various types of anthropogenic water pollution (heavy metals, PCBs, PAH, mixed pollution) on the activity of glutathione-S-transferase (GST), and enzymes at phase II of xenobiotic biotransformation in different fish species has been studied. Their ecological-biochemical role in development of responses to toxic impact is demonstrated. We stress the need for detailed research into GST isoenzyme composition since there is no agreement as to expediency of using this enzyme as a biomarker of water pollution because the results obtained are rather contradictory. One of the reasons for that is very poor knowledge of the isoenzyme composition and group distribution of GST family representatives in fish.